STS-116 was a Space Shuttle mission to the International Space Station (ISS) flown by Space Shuttle Discovery . Liftoff was originally scheduled for December 7, 2006, but that attempt was canceled due to a low cloud ceiling. Discovery successfully lifted off during the second launch attempt on Saturday, December 9, 2006 at 8:47:35 p.m. EST. It was the first night launch of a Space Shuttle orbiter since STS-113, which launched on November 23, 2002.

The mission is also referred to as ISS-12A.1 by the ISS program. The main goals of the mission were delivery and attachment of the International Space Station's third port truss segment (the P5 truss), major rewiring of the station's power system, and exchange of ISS Expedition 14 personnel. The shuttle landed at 5:32 p.m. EST on Friday, December 22, 2006 at Kennedy Space Center, a delay of 98 minutes from schedule due to unfavorable weather conditions. This mission was particularly notable to Sweden since it's the first time a Scandinavian astronaut (Christer Fuglesang) has visited space.

STS-116 was the final scheduled Space Shuttle flight planned for launch from Pad 39B as NASA reconfigures the pad for Ares I launches. The only remaining use of Pad 39B by Shuttles is as a reserve for a potential STS-3xx rescue mission for STS-125, the final Hubble Space Telescope servicing mission.

STS-116 was the last flight of Discovery before maintenance; the next Discovery mission was STS-120, which launched on 2007-10-23.

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